Brentford can make it six points out of a possible nine at the start of the season by beating newly-promoted Southampton at home.
The Bees edged out Crystal Palace 2-1 on the opening weekend at the Gtech Community Stadium before going down 2-0 at Liverpool last time out, but they should get back to winning ways by seeing off Saints, who are yet to pick up a victory upon their return to the top flight.
Ivan Toney was left out for the defeat at Anfield as speculation continues over his future and it is unclear if the striker will come back into the fold for the visit of Southampton.
The Bees have signed young Brazilian forward Gustavo Nunes this week and he could be handed an immediate debut, but Igor Thiago, Rico Henry, Aaron Hickey and Josh Dasilva all remain out injured.
Southampton will hope keeper Aaron Ramsdale can be registered in time to play following his £25million move from Arsenal with the England man set to replace Alex McCarthy in goal for the visitors.
Saints boss Russell Martin also rang the changes for the midweek cup win over Cardiff, so he will bring back the majority of the players who have lined up in the league matches so far, although Cameron Archer could keep his place in the side after scoring twice against the Bluebirds.
Ross Stewart remains doubtful for the visitors, but Kamaldeen Sulemana is set to be available after recovering from injury.