Having spent last season out of Europe following a dismal eighth-placed finish in the 2022/23 season, Ange Postecoglou helped guide his side to a respectable fifth-placed finish last term.
And just three years on from their last appearance in the Europa League in March 2021, their squad is almost unrecognisable.
Just one player remains from the starting XI that suffered a shock 3-0 defeat away at Dinamo Zagreb in the last 16 second leg.
Spurs seemed destined to reach the quarter-finals following a 2-0 first leg victory, with Harry Kane helping himself to a double.
But he drew a blank in the return fixture away at the Croatian side, having been denied twice by goalkeeper Dominik Livakovic.
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His misses proved costly, with a hat-trick from Mislav Orsic compounding Spurs to an embarrassing exit from what was expected to be a comfortable win.
Their performance left then-boss Jose Mourinho to issue a heartfelt apology to the club’s supporters, while also lamenting the attitude from his men.
Meanwhile former skipper Hugo Lloris hit out at his teammates, as he said: “I think we are more than disappointed, it is a disgrace. I hope everyone in the changing room feels responsible.”
Before adding: “We have a lack of basics, fundamentals, our performances are just in relation of that. Mentally we should be stronger, more competitive.”
Here talkSPORT.com takes a look at Spurs’ starting XI from that fateful night in Croatia, with ten of those players no longer on their books.